Bacteria:Article Title: Antibiotic macrocycle compounds and methods of manufacture and use thereof
Article Snippet: .. TABLE 2 MIC data for OPT-80 and Formula II for a panel of aerobic bacteria Aerobic Panel MIC (μg/mL) ORG 84 ORG 97 ORG 98 ORG 83 E. faecium ORG 85 S. aureus S. aureus ORG 101 E. faecalis ATCC E. faecium (MRSA) (MSSA) ORG 99 S. pyogenes ATCC 700221 ATCC ATCC ATCC S. epidermidis ATCC Compound 29212 VRE 19434 33591 29213 ATCC 12228 19615 OPT-80 2-4 4 8 8 8 4 16-32 Formula 16-64 >32 >64 >64 >64 >32 >32 II TABLE 3 MIC data for OPT-80 and Formula II for a panel of anaerobic bacteria Aerobic Panel MIC (μg/mL) ORG 830 C. difficile ORG 150 B. fragilis Compound ATCC 700057 25285 OPT-80 0.030, 0.06 >16 Formula II 0.5-1 >16 Effect of Fecal Material on In Vitro Activity of OPT-80 and Formula II: The effect of fecal material on the antimicrobial activity of OPT-80, Formula II and vancomycin, which is the only FDA approved treatment for CDAD, was evaluated vs. C. difficile ATCC strain 700057 (Table 3). ..
Article Title: Antibiotic macrocycle compounds and methods of manufacture and use thereof
Article Snippet: .. TABLE 2 MIC data for OPT-80 and Formula II for a panel of aerobic bacteria Aerobic Panel MIC (μg/mL) ORG 84 ORG 97 ORG 98 ORG 83 E. faecium ORG 85 S. aureus S. aureus ORG 101 E. faecalis ATCC F. faecium (MRSA) (MSSA) ORG 99 S. pyogenes ATCC 700221 ATCC ATCC ATCC S. epidermidis ATCC Compound 29212 VRE 19434 33591 29213 ATCC 12228 19615 OPT-80 2-4 4 8 8 8 4 16-32 Formula 16-64 >32 >64 >64 >64 >32 >32 II TABLE 3 MIC data for OPT-80 and Formula II for a panel of anaerobic bacteria Aerobic Panel MIC (μg/mL) ORG 830 ORG 150 C. difficile B. fragilis Compound ATCC 700057 25285 OPT-80 0.030, 0.06 >16 Formula II 0.5-1 >16 Effect of Fecal Material on In Vitro Activity of OPT-80 and Formula II: The effect of fecal material on the antimicrobial activity of OPT-80, Formula II and vancomycin, which is the only FDA approved treatment for CDAD, was evaluated vs. C. difficile ATCC strain 700057 (Table 3). ..
In Vitro:Article Title: Antibiotic macrocycle compounds and methods of manufacture and use thereof
Article Snippet: .. TABLE 2 MIC data for OPT-80 and Formula II for a panel of aerobic bacteria Aerobic Panel MIC (μg/mL) ORG 84 ORG 97 ORG 98 ORG 83 E. faecium ORG 85 S. aureus S. aureus ORG 101 E. faecalis ATCC E. faecium (MRSA) (MSSA) ORG 99 S. pyogenes ATCC 700221 ATCC ATCC ATCC S. epidermidis ATCC Compound 29212 VRE 19434 33591 29213 ATCC 12228 19615 OPT-80 2-4 4 8 8 8 4 16-32 Formula 16-64 >32 >64 >64 >64 >32 >32 II TABLE 3 MIC data for OPT-80 and Formula II for a panel of anaerobic bacteria Aerobic Panel MIC (μg/mL) ORG 830 C. difficile ORG 150 B. fragilis Compound ATCC 700057 25285 OPT-80 0.030, 0.06 >16 Formula II 0.5-1 >16 Effect of Fecal Material on In Vitro Activity of OPT-80 and Formula II: The effect of fecal material on the antimicrobial activity of OPT-80, Formula II and vancomycin, which is the only FDA approved treatment for CDAD, was evaluated vs. C. difficile ATCC strain 700057 (Table 3). ..
Article Title: Antibiotic macrocycle compounds and methods of manufacture and use thereof
Article Snippet: .. TABLE 2 MIC data for OPT-80 and Formula II for a panel of aerobic bacteria Aerobic Panel MIC (μg/mL) ORG 84 ORG 97 ORG 98 ORG 83 E. faecium ORG 85 S. aureus S. aureus ORG 101 E. faecalis ATCC F. faecium (MRSA) (MSSA) ORG 99 S. pyogenes ATCC 700221 ATCC ATCC ATCC S. epidermidis ATCC Compound 29212 VRE 19434 33591 29213 ATCC 12228 19615 OPT-80 2-4 4 8 8 8 4 16-32 Formula 16-64 >32 >64 >64 >64 >32 >32 II TABLE 3 MIC data for OPT-80 and Formula II for a panel of anaerobic bacteria Aerobic Panel MIC (μg/mL) ORG 830 ORG 150 C. difficile B. fragilis Compound ATCC 700057 25285 OPT-80 0.030, 0.06 >16 Formula II 0.5-1 >16 Effect of Fecal Material on In Vitro Activity of OPT-80 and Formula II: The effect of fecal material on the antimicrobial activity of OPT-80, Formula II and vancomycin, which is the only FDA approved treatment for CDAD, was evaluated vs. C. difficile ATCC strain 700057 (Table 3). ..
Activity Assay:Article Title: Antibiotic macrocycle compounds and methods of manufacture and use thereof
Article Snippet: .. TABLE 2 MIC data for OPT-80 and Formula II for a panel of aerobic bacteria Aerobic Panel MIC (μg/mL) ORG 84 ORG 97 ORG 98 ORG 83 E. faecium ORG 85 S. aureus S. aureus ORG 101 E. faecalis ATCC E. faecium (MRSA) (MSSA) ORG 99 S. pyogenes ATCC 700221 ATCC ATCC ATCC S. epidermidis ATCC Compound 29212 VRE 19434 33591 29213 ATCC 12228 19615 OPT-80 2-4 4 8 8 8 4 16-32 Formula 16-64 >32 >64 >64 >64 >32 >32 II TABLE 3 MIC data for OPT-80 and Formula II for a panel of anaerobic bacteria Aerobic Panel MIC (μg/mL) ORG 830 C. difficile ORG 150 B. fragilis Compound ATCC 700057 25285 OPT-80 0.030, 0.06 >16 Formula II 0.5-1 >16 Effect of Fecal Material on In Vitro Activity of OPT-80 and Formula II: The effect of fecal material on the antimicrobial activity of OPT-80, Formula II and vancomycin, which is the only FDA approved treatment for CDAD, was evaluated vs. C. difficile ATCC strain 700057 (Table 3). ..
Article Title: Antibiotic macrocycle compounds and methods of manufacture and use thereof
Article Snippet: .. TABLE 2 MIC data for OPT-80 and Formula II for a panel of aerobic bacteria Aerobic Panel MIC (μg/mL) ORG 84 ORG 97 ORG 98 ORG 83 E. faecium ORG 85 S. aureus S. aureus ORG 101 E. faecalis ATCC F. faecium (MRSA) (MSSA) ORG 99 S. pyogenes ATCC 700221 ATCC ATCC ATCC S. epidermidis ATCC Compound 29212 VRE 19434 33591 29213 ATCC 12228 19615 OPT-80 2-4 4 8 8 8 4 16-32 Formula 16-64 >32 >64 >64 >64 >32 >32 II TABLE 3 MIC data for OPT-80 and Formula II for a panel of anaerobic bacteria Aerobic Panel MIC (μg/mL) ORG 830 ORG 150 C. difficile B. fragilis Compound ATCC 700057 25285 OPT-80 0.030, 0.06 >16 Formula II 0.5-1 >16 Effect of Fecal Material on In Vitro Activity of OPT-80 and Formula II: The effect of fecal material on the antimicrobial activity of OPT-80, Formula II and vancomycin, which is the only FDA approved treatment for CDAD, was evaluated vs. C. difficile ATCC strain 700057 (Table 3). ..
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